Research Articles

Design of universal Ebola virus vaccine candidates via immunofocusing
Duo Xu, Abigail E Powell, Ashley Utz, Mrinmoy Sanyal, Jonathan Do, JJ Patten, Juan I Moliva, Nancy J Sullivan, Robert A Davey, Peter S Kim

Proceedings of the National Academy of Sciences (2024), bioRxiv (2023).
https://www.pnas.org/doi/10.1073/pnas.2316960121

Vaccine design via antigen reorientation
Duo Xu, Joshua J. Carter, Chunfeng Li, Ashley Utz, Payton A. B. Weidenbacher, Shaogeng Tang, Mrinmoy Sanyal, Bali Pulendran, Christopher O. Barnes, Peter S. Kim

Nature Chemical Biology (2024), bioRxiv (2022).
https://www.nature.com/articles/s41589-023-01529-6

PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity
Wei Wei, Xuchao Lyu, Andrew L. Markhard, Sipei Fu, Rachel E. Mardjuki, Peter E. Cavanagh, Xianfeng Zeng, Jakub Rajniak, Nannan Lu, Shuke Xiao, Meng Zhao, Maria Dolores Moya-Garzon, Steven D. Truong, Jonathan Chiu‐Chun Chou, Lianna W. Wat, Saranya Chidambaranathan-Reghupaty, Laetitia Coassolo, Duo Xu, Fangfang Shen, Wentao Huang, Cuauhtemoc B. Ramirez, Cholsoon Jang, Lingyin Li, Katrin J. Svensson, Michael A. Fischbach & Jonathan Z. Long

Nature (2024), bioRxiv (2024)
https://www.nature.com/articles/s41586-024-07801-6

Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lung
Timothy Ting-Hsuan Wu†, Kyle J Travaglini†, Arjun Rustagi†, Duo Xu, Yue Zhang, Sori K Jang, Astrid Gillich, Roozbeh Dehghannasiri, Giovanny Martinez-Colon, Aimee Beck, Aaron J Wilk, Maurizio Morri, Winston L Trope, Joseph B Shrager, Steve R Quake, Christin S Kuo, Julia Salzman, Peter S Kim, Catherine A Blish, Mark A Krasnow (†Equal contribution)

Journal of Experimental Medicine (2024), bioRxiv (2022)
https://doi.org/10.1084/jem.20232192

Lactate oxidase nanocapsules boost T cell immunity and efficacy of cancer immunotherapy
Zheng Cao, Duo Xu, Jeffrey Harding, Wenting Chen, Xiangsheng Liu, Zi Wang, Lan Wang, Tong Qi, Shilin Chen, Xinheng Guo, Irvin SY Chen, Jimin Guo, Yunfeng Lu, Jing Wen

Science Translational Medicine (2023)
https://www.science.org/doi/abs/10.1126/scitranslmed.add2712

Efficient evolution of human antibodies from general protein language models
Brian L Hie, Varun R Shanker, Duo Xu, Theodora UJ Bruun, Payton A Weidenbacher, Shaogeng Tang, Wesley Wu, John E Pak, Peter S Kim

Nature Biotechnology (2023)
https://www.nature.com/articles/s41587-023-01763-2

Multimerization of Ebola GPΔmucin on protein nanoparticle vaccines has minimal effect on elicitation of neutralizing antibodies
Abigail E Powell, Duo Xu, Gillie A Roth, Kaiming Zhang, Wah Chiu, Eric A Appel, Peter S Kim

Frontiers in Immunology (2022)
https://www.frontiersin.org/articles/10.3389/fimmu.2022.942897/full

Enzyme therapeutic for ischemia and reperfusion injury in organ transplantation
Ran Yan, Jie Ren, Jing Wen, Zheng Cao, Di Wu, Meng Qin, Duo Xu, Roxanne Castillo, Feifei Li, Fang Wang, Zhihua Gan, Chaoyong Liu, Ping Wei, Yunfeng Lu

Advanced Materials (2022)
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202105670

Systemic delivery of microRNA for treatment of brain ischemia
Chaoyong Liu, Jing Wen, Dai Li, Hongzhao Qi, Lina Nih, Jialin Zhu, Duo Xu, Yu Ren, Shanshan Zhang, Donglin Han, Huanhuan Jia, Junhu Zhou, Meng Qin, Jialing Wu, Xubo Yuan, Ji Liu, Jin Zhao, Chunsheng Kang, Yunfeng Lu

Nano Research (2022)
https://link.springer.com/article/10.1007/s12274-021-3413-8

Dual redox mediators accelerate the electrochemical kinetics of lithium-sulfur batteries
Fang Liu, Geng Sun, Hao Bin Wu, Gen Chen, Duo Xu, Runwei Mo, Li Shen, Xianyang Li, Shengxiang Ma, Ran Tao, Xinru Li, Xinyi Tan, Bin Xu, Ge Wang, Bruce S Dunn, Philippe Sautet, Yunfeng Lu

Nature communications (2020)
https://www.nature.com/articles/s41467-020-19070-8

Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates
Meng Qin, Lan Wang, Di Wu, Christopher K Williams, Duo Xu, Emiko Kranz, Qi Guo, Jiaoqiong Guan, Harry V Vinters, YooJin Lee, Yiming Xie, Yun Luo, Guibo Sun, Xiaobo Sun, Zhanlong He, Yunfeng Lu, Masakazu Kamata, Jing Wen, Irvin SY Chen

Frontiers in Immunology (2020)
https://www.frontiersin.org/articles/10.3389/fimmu.2019.03132/full

Real-time quantification of cell internalization kinetics by functionalized bioluminescent nanoprobes
Di Wu, Yilong Yang, Pengcheng Xu, Duo Xu, Yang Liu, Roxanne Castillo, Ran Yan, Jie Ren, George Zhou, Chaoyong Liu, Meng Qin, Juanjuan Du, Lihua Hou, Irvin Chen, Chunsheng Kang, Lihua Jin, Jing Wen, Wei Chen, Yunfeng Lu

Advanced Materials (2019)
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201902469

Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice
Jing Wen, Di Wu, Meng Qin, Chaoyong Liu, Lan Wang, Duo Xu, Harry V Vinters, Yang Liu, Emiko Kranz, Xin Guan, Guibo Sun, Xiaobo Sun, YooJin Lee, Otoniel Martinez-Maza, Daniel Widney, Yunfeng Lu, Irvin SY Chen, Masakazu Kamata

Nature Biomedical Engineering (2019)
https://www.nature.com/articles/s41551-019-0434-z

Efficient delivery of nerve growth factors to the central nervous system for neural regeneration
Duo Xu, Di Wu, Meng Qin, Lina R Nih, Chaoyong Liu, Zheng Cao, Jie Ren, Xiangjun Chen, Zhanlong He, Wenhai Yu, Jiaoqiong Guan, Suqin Duan, Fang Liu, Xiangsheng Liu, Jesse Li, Dushawn Harley, Bin Xu, Lihua Hou, Irvin SY Chen, Jing Wen, Wei Chen, Sina Pourtaheri, Yunfeng Lu

Advanced Materials (2019)
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201900727

Systemic delivery of monoclonal antibodies to the central nervous system for brain tumor therapy
Lei Han, Chaoyong Liu, Hongzhao Qi, Junhu Zhou, Jing Wen, Di Wu, Duo Xu, Meng Qin, Jie Ren, Qixue Wang, Lixia Long, Yang Liu, Irvin Chen, Xubo Yuan, Yunfeng Lu, Chunsheng Kang

Advanced Materials (2019)
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201805697

A bioinspired platform for effective delivery of protein therapeutics to the central nervous system
Di Wu†, Meng Qin†, Duo Xu†, Lan Wang, Chaoyong Liu, Jie Ren, George Zhou, Chen Chen, Fengmei Yang, Yanyan Li, Yuan Zhao, Ruyi Huang, Sina Pourtaheri, Chunsheng Kang, Masakazu Kamata, Irvin SY Chen, Zhanlong He, Jing Wen, Wei Chen, Yunfeng Lu (†Equal contribution)

Advanced Materials (2019)
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201807557

A hepatocyte-mimicking antidote for alcohol intoxication
Duo Xu, Hui Han, Yuxin He, Harrison Lee, Di Wu, Fang Liu, Xiangsheng Liu, Yang Liu, Yunfeng Lu, Cheng Ji

Advanced Materials (2018)
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201707443

Nanocapsules of oxalate oxidase for hyperoxaluria treatment
Ming Zhao, Duo Xu, Di Wu, James W Whittaker, Robert Terkeltaub, Yunfeng Lu

Nano Research (2018)
https://link.springer.com/article/10.1007/s12274-017-1898-3

Fabrication of hybrid silicate coatings by a simple vapor deposition method for lithium metal anodes
Fang Liu, Qiangfeng Xiao, Hao Bin Wu, Li Shen, Duo Xu, Mei Cai, Yunfeng Lu

Advanced Energy Materials (2018)
https://onlinelibrary.wiley.com/doi/abs/10.1002/aenm.201701744

Protein Nanocapsules for Therapeutic Applications
Duo Xu

University of California, Los Angeles | Doctoral Thesis (2019)
https://www.proquest.com/openview/a6334877b05b8d74790c29d6482b433d/1?pq-origsite=gscholar&cbl=18750&diss=y

Nanocapsules of therapeutic proteins with enhanced stability and long blood circulation for hyperuricemia management
Xiaopei Zhang, Duo Xu, Xin Jin, Gan Liu, Sheng Liang, Hui Wang, Wei Chen, Xinyuan Zhu, Yunfeng Lu

Journal of Controlled Release (2017)
https://www.sciencedirect.com/science/article/pii/S0168365916307908

Prolonging the plasma circulation of proteins by nano-encapsulation with phosphorylcholine-based polymer
Linlin Zhang, Yang Liu, Gan Liu, Duo Xu, Sheng Liang, Xinyuan Zhu, Yunfeng Lu, Hui Wang

Nano Research (2016)
https://link.springer.com/article/10.1007/s12274-016-1128-4

An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules
Jie Li, Linlin Zhang, Yang Liu, Jing Wen, Di Wu, Duo Xu, Tatiana Segura, Jing Jin, Yunfeng Lu, Hui Wang

Chemical Communications (2016)
https://pubs.rsc.org/en/content/articlehtml/2016/cc/c6cc05099a

Structural insight into the type-II mitochondrial NADH dehydrogenases
Yue Feng, Wenfei Li, Jian Li, Jiawei Wang, Jingpeng Ge, Duo Xu, Yanjing Liu, Kaiqi Wu, Qingyin Zeng, Jia-Wei Wu, Changlin Tian, Bing Zhou, Maojun Yang

Nature (2012)
https://www.nature.com/articles/nature11541